8-night Upper Mississippi River Cruise

September 12, 2026

American Cruise Lines: American Serenade

St. Paul/St. Louis

Vacation Offer ID 1560777

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The Signature Collection – Exclusive Amenities
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Cruise Inclusions

Cruise
Meals
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Destination Guide
Suggested Shore Excursions

Destination	Arrival	Departure
St. Paul St. Paul 09/12/2026 In St. Paul, a stroll down Summit Avenue unveils a captivating array of historic mansions, each with its own story to tell from the late 1800s. For a shopping extravaganza like no other, venture into the vast expanse of the Mall of America, boasting over 500 stores alongside an indoor water park and theme park for endless entertainment.	09/12/2026	09/12/2026
Mississippi River Cruising Mississippi River Cruising 09/13/2026 A day on the river is not a day lost. Grab a book, a friend, a game, or an on board expert and take the day as it comes as we navigate the Mississippi from St. Paul to La Crosse, WA. Engage in curated activities, from destination-focused enrichment programs led by esteemed guest speakers to stimulating Art and App-titude Classes, and group Cooking Demonstrations. Embrace spirited camaraderie with Mixology sessions, Trivia challenges, and Game Shows. Elevate your journey with a blend of leisure and refinement, where every moment is enriched by the timeless charm of riverboat travel.	09/13/2026	09/13/2026
La Crosse La Crosse 09/14/2026 Step into 19th-century America in La Crosse, situated on the banks of three captivating rivers. Riverside Park offers a spectacle of beautiful gardens, an outdoor performance center, and inspiring sculptures that ignite the imagination.	09/14/2026	09/14/2026
Mississippi River Cruising Mississippi River Cruising 09/15/2026 With the wide Mississippi River before you, relish the quiet sounds of the river. Relax on your private balcony and watch the riverbanks come to life with a vast array of wildlife that call these shores home or learn the stories of the area around you from the on-board expert. The day is yours, wander to the sun deck for the best views of the winding river. Enjoy live music, but wherever you roam, don’t forget to stop by the restaurant for freshly baked cookies at 3 pm daily.	09/15/2026	09/15/2026
Dubuque Dubuque 09/16/2026 Dubuque is a true masterpiece along the upper Mississippi River. As one of the oldest settlements west of the great river, Dubuque wears its history proudly while staying a modern hub for commerce, industry, education, and culture.	09/16/2026	09/16/2026
Davenport Davenport 09/17/2026 Step into Davenport, the largest cruise port between St. Louis and St. Paul, a key city within the dynamic "Quad Cities" that merge into an extensive metro area. History marked its presence here when the first railroad to cross the Mississippi River connected Chicago to Rock Island, Illinois, just across the river.	09/17/2026	09/17/2026
Hannibal Hannibal 09/18/2026 Welcome to Hannibal, Missouri, a charming riverside town brimming with character. At the heart of Hannibal lies the legacy of its most famous resident, Mark Twain, whose childhood adventures served as the inspiration for some of literature's most beloved characters. Explore Twain's boyhood home, a beautifully preserved white clapboard house where the author spent his formative years. Nearby, the Mark Twain Boyhood Home & Museum offers a fascinating glimpse into Twain's life and works, including original manuscripts, rare artifacts, and interactive exhibits that bring his stories to life in vivid detail.	09/18/2026	09/18/2026
St. Louis (Alton) St. Louis (Alton) 09/19/2026 Tucked away beneath the majestic limestone bluffs lies the charming port of Alton, Illinois, serving as a gateway to endless adventures in St. Louis and beyond. Follow the footsteps of the great Lewis and Clark on an exciting excursion through the Lewis and Clark Confluence Tower where you can see the Mississippi from new heights. Learn about the fascinating tales of this famed river, exploring its extensive history, the communities it sustains, and the diverse ecosystems it nurtures.	09/19/2026	09/19/2026
St. Louis St. Louis 09/20/2026 Enjoy breakfast onboard the ship as you prepare for your journey home. Reflect upon the memorable experiences and the new friendships forged during your time with us.	09/20/2026	09/20/2026

American Cruise Lines: American Serenade

American Serenade won Cruise Critic’s Editors’ Picks Award for Best New River Cruise Ship of the Year recently, the first time an American ship has received this prestigious award. Introduces an updated modern interior design, integrating an elegant and refined aesthetic with tradition for the spacious comfort found aboard all of ships Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.

Ship Statistics

Maiden Voyage: 2023
Passenger Capacity: 175
Number of Staterooms: 91

Number of Suites: 16
Wheelchair Accessible: Yes

Suite

Veranda Suite (Private Balcony) (VS) Call for pricing

Category: VS
Deck 4

With a generous 405 sq. ft. of relaxing space, each Veranda suite includes a private walk-out balcony to enjoy the panoramic views. Considered one of the finest staterooms on any cruise ship, guests will enjoy full-size bathrooms and large living area with sliding glass door.

Grand Suite (Private Balcony) (GS) Call for pricing

Category: GS
Deck 4

The luxurious Grand Suite measures 650 sq. ft. and offers panoramic views through floor-to-ceiling glass windows. Sliding glass doors lead out to a private balcony complete with a private dining area, the perfect place to enjoy breakfast room service or watch the sun set. Each Grand Suite features a separate bedroom and living area, ideal for gathering with family and friends after an invigorating day of exploration.

Balcony

Single (Private Balcony) (SGB) Call for pricing

Category: SGB
Deck 4
Deck 3
Deck 2

Perfect for the solo traveler, the Single staterooms offer all of the amenities you expect from a fine hotel. At 250 sq. ft., these staterooms have spacious bathrooms and large sliding glass doors that lead to a private balcony.

Balcony Stateroom (AAR) Call for pricing

Category: AAR
Deck 1

AAR staterooms on the main deck offer complete comfort with approximately 275 sq. ft. of living space. Enjoy a full-size bathroom, large picture window, and door leading out to a furnished private balcony. These staterooms also feature a large sitting area, ideal for getting together with friends.

Balcony Stateroom (AAM) Call for pricing

Category: AAM
Deck 3

Located on the third deck, these spacious staterooms feature commanding views of the passing river landscapes. At 350 sq. ft., there is plenty of room to enjoy the tasteful comfort of your surroundings. These staterooms have all the comforts of a fine hotel and feature floor-to-ceiling sliding glass doors with a private balcony to offer panoramic views from every angle.

Balcony Stateroom (AAC) Call for pricing

Category: AAC
Deck 2

AAC staterooms are conveniently located on the second deck and offer all of the comforts of a fine hotel. Complete with a private balcony and floor-to-ceiling sliding glass doors, these staterooms provide spectacular views of the surrounding landscape. At 316 sq. ft., these staterooms also offer a sitting area, desk and full-size bathrooms.

Prices are per person based on double occupancy. Pricing on some sailings may reflect special limited time offers, not combinable with any other offers/discounts. Valid on new bookings only. American Cruise Lines includes all shipboard meals, entertainment, tips and gratuities, alcohol, and other port charges and fees in the price of the cruise. Many shore excursions are also included in the cost of the cruise.

All fares are quoted in US Dollars.

Deck 5