8-night Upper Mississippi River Cruise

July 18, 2025

American Cruise Lines: American Serenade

St. Paul/St. Louis

Vacation Offer ID 1507108

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Cruise Theme: Mark Twain Cruise

Explore the Mississippi's Literary History, with a Stop at Hannibal, MO. Few American authors are as beloved as Samuel Clemens, better known by his pen name, Mark Twain. On this special theme cruise, explore the river that served as his inspiration, complete with a true-to-life Mark Twain impersonator, and a stop in Hannibal, MO, Twain's hometown.

The Signature Collection – A Hosted Sailing
Hosted Sailings offer Outstanding Value, Exclusive Amenities and an Experienced Personable Host on board to ensure your cruise is more enjoyable.

Cruise Inclusions

Cruise
Meals
Entertainment and more

Destination Guide
Suggested Shore Excursions

Destination	Arrival	Departure
St. Paul St. Paul 07/19/2025 The Twin Cities offer world-class art galleries, museums, and live performances. St. Paul’s Summit Avenue showcases gorgeous historic mansions built in the late 1800s. The enormous Mall of America includes more than 500 stores and an indoor waterpark and theme park. View gorgeous panoramas of the city from Mounds Park and cherish the enchantment of Minnehaha Falls with its 53-foot cascade. Settle into your hotel and enjoy the city at your leisure.	07/19/2025	07/19/2025
Mississippi River Cruising Mississippi River Cruising 07/20/2025 Board your ship and be treated to a Welcome Reception. Get to know your fellow guests and savor the view as you set out cruising Mark Twain’s river. Admire the breathtaking scenery that has inspired the country’s most legendary writers, artists, and musicians.	07/20/2025	07/20/2025
La Crosse La Crosse 07/21/2025 Step into 19th-century America in La Crosse, located on the banks of three captivating rivers. La Crosse is home to Riverside Park, where you’ll discover beautiful gardens, an outdoor performance center, and inspiring sculptures. Enjoy breathtaking, panoramic views from Grand Dad’s Bluff, a 600-ft high bluff which overlooks the entire city. Led by a local expert, gain insight into the city’s development from the boomtown riverboat days through the roaring ‘20s to the challenges and opportunities of the 21st century.	07/21/2025	07/21/2025
River Cruising River Cruising 07/22/2025 As you make your way from Lacrosse to Dubuque, reflect upon the rich history of the Mississippi River and the variety of music born upon its shores. Listen to the talented performers in one of our lounges or share the afternoon with fellow travelers.	07/22/2025	07/22/2025
Dubuque Dubuque 07/23/2025 A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the Mississippi River and continues today as a primary commercial, industrial, educational, and cultural center for this region. From the ship, it’s a short walk to a cruise highlight at the incredible complex of the Smithsonian-affiliated National Mississippi River Museum & Aquarium. View colorful Victorian mansions on a stroll through the quaint downtown area, take a ride on the world’s shortest and steepest scenic railway, or try your luck in one of Dubuque's state-of-the-art casinos. Visit one of the oldest catholic churches in the city and enjoy the lovely landscapes of the Dubuque Arboretum & Botanical Garden.	07/23/2025	07/23/2025
Davenport Davenport 07/24/2025 Davenport is your largest cruise port between St. Louis and St. Paul as one of the four “Quad Cities” that combine into a larger metro area. The first railroad to reach the Mississippi River connected Chicago to Rock Island, Illinois across the river. The area features diverse attractions ranging from grand historic mansions lining the river, renowned museums, rich Native American history, and the largest agricultural exhibit in the world. Be enlightened by the region’s history, culture, and environment at the Smithsonian-affiliated Putnam Museum. Learn how American ingenuity impowers the Midwest’s ability to feed the nation at the expansive John Deere Pavilion as you amble through interactive exhibits of vintage and modern high-tech equipment that reveal the evolution of inventions that revolutionized American farming.	07/24/2025	07/24/2025
Hannibal Hannibal 07/25/2025 Explore Hannibal, “America’s Hometown,” a mere block from the ship, where Mark Twain’s home and museum illuminate the events that shaped his life and career. Elements of his childhood adventures were woven into classics like The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn. Run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. Explore other nearby museums and the charming downtown Main Street with unique shops, art galleries, and tasty temptations.	07/25/2025	07/25/2025
St. Louis	07/26/2025	07/26/2025
St. Louis (Alton) St. Louis (Alton) 07/26/2025 St. Louis is often referred to as the “Gateway to the West.” Take in the Gateway Arch Riverfront, highlighted by the Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis' many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens. Alton is an idyllic town, known for its scenic limestone bluffs along the river and its rich Civil War history. The National Great Rivers Museum, located at the Melvin Price Lock and Dam, tells the stories of the Mississippi River’s history, the people that rely on the River, and its many ecosystems. Hometown of jazz musician Miles Davis and Robert Wadlow, the tallest known person in history (8’11”), Alton is an inspiring and picturesque destination and the perfect place to begin your Upper Mississippi journey.	07/26/2025	07/26/2025
St. Louis (Alton) St. Louis (Alton) 07/27/2025 Enjoy breakfast on board the ship, before beginning your journey home. Reflect upon your adventures and the new friends made along the way.	07/27/2025	07/27/2025
St. Louis	07/27/2025	07/27/2025

American Cruise Lines: American Serenade

American Serenade won Cruise Critic’s Editors’ Picks Award for Best New River Cruise Ship of the Year recently, the first time an American ship has received this prestigious award. Introduces an updated modern interior design, integrating an elegant and refined aesthetic with tradition for the spacious comfort found aboard all of ships Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.

Ship Statistics

Maiden Voyage: 2023
Passenger Capacity: 175
Number of Staterooms: 91

Number of Suites: 16
Wheelchair Accessible: Yes

Suite

Veranda Suite (Private Balcony) (VS) Call for pricing

Category: VS
Deck 4

With a generous 405 sq. ft. of relaxing space, each Veranda suite includes a private walk-out balcony to enjoy the panoramic views. Considered one of the finest staterooms on any cruise ship, guests will enjoy full-size bathrooms and large living area with sliding glass door.

Grand Suite (Private Balcony) (GS) Call for pricing

Category: GS
Deck 4

The luxurious Grand Suite measures 650 sq. ft. and offers panoramic views through floor-to-ceiling glass windows. Sliding glass doors lead out to a private balcony complete with a private dining area, the perfect place to enjoy breakfast room service or watch the sun set. Each Grand Suite features a separate bedroom and living area, ideal for gathering with family and friends after an invigorating day of exploration.

Balcony

Single (Private Balcony) (SGB) Call for pricing

Category: SGB
Deck 4
Deck 3
Deck 2

Perfect for the solo traveler, the Single staterooms offer all of the amenities you expect from a fine hotel. At 250 sq. ft., these staterooms have spacious bathrooms and large sliding glass doors that lead to a private balcony.

Balcony Stateroom (AAR) Call for pricing

Category: AAR
Deck 1

AAR staterooms on the main deck offer complete comfort with approximately 275 sq. ft. of living space. Enjoy a full-size bathroom, large picture window, and door leading out to a furnished private balcony. These staterooms also feature a large sitting area, ideal for getting together with friends.

Balcony Stateroom (AAM) Call for pricing

Category: AAM
Deck 3

Located on the third deck, these spacious staterooms feature commanding views of the passing river landscapes. At 350 sq. ft., there is plenty of room to enjoy the tasteful comfort of your surroundings. These staterooms have all the comforts of a fine hotel and feature floor-to-ceiling sliding glass doors with a private balcony to offer panoramic views from every angle.

Balcony Stateroom (AAC) Call for pricing

Category: AAC
Deck 2

AAC staterooms are conveniently located on the second deck and offer all of the comforts of a fine hotel. Complete with a private balcony and floor-to-ceiling sliding glass doors, these staterooms provide spectacular views of the surrounding landscape. At 316 sq. ft., these staterooms also offer a sitting area, desk and full-size bathrooms.

Fares listed are per person, based on double occupancy and include all gratuities, port charges and fees.

Prices are per person based on double occupancy. Pricing on some sailings may reflect special limited time offers, not combinable with any other offers/discounts. Valid on new bookings only. American Cruise Lines includes all shipboard meals, entertainment, tips and gratuities, alcohol, and other port charges and fees in the price of the cruise. Many shore excursions are also included in the cost of the cruise.

All fares are quoted in US Dollars.

Deck 5